Endocrine Abstracts

The incidence of well differentiated thyroid carcinoma (TC), mostly papillary, is higher among patients with primary hyperparathyroidism (PHPT) compared to the general population, despite the similar frequency of thyroid nodules. The link between TC and Hashimoto thyroiditis (HT) is attributed to chronic inflammation, but the molecular association is poorly undestood. Herein, we explore the possible interplay between HT, PHPT and papillary TC through a case report and a litera...

Background: Functional studies demonstrate that Armadillo repeat-containing 5 (ARMC5) gene, controls apoptosis and steroid synthesis. A germline mutations in ARMC5 are recently been associated with Cushing syndrome and possibly can be responsible for a broader tumor predisposition.Case presentation: A 51-year-old woman presented with intermittent rectal bleeding. A colonoscopy revealed multiple colonic polyps, histopathological analysis showed tubular ad...

Autoimmune polyglandular syndromes (APS) are a rare group of autoimmune disorders that affect more than one endocrine gland, although non-endocrine organs can be involved. Concerning the variable evolution of this clinical entity over time, our case aims to emphasise the importance of regular follow-up and screening for polyglandular autoimmunity in selected patients in order to decrease a possibility of future complications consistent with APS. We report the case of a 20-year...

Because of quite variable clinical manifestations of Cushing’s syndrome and overlap with more common medical problems, its diagnosis is frequently mistaken, with consequent considerable delay from the first presentation to a different primary and secondary care physicians to a final diagnosis, often made by endocrinologist. The diagnostic latency in reported studies vary from six months to ten years. We report a case of a 54-years-old female admitted to the hospital thro...

Menstrual irregularity is common in women with acromegaly, occurring in 40–84% of patients. Its pathogenesis is still not well established although it is usually attributed to prolactin excess and/or gonadotropin deficiency. Also, since the presence of growth hormone (GH) and insulin-like growth factor 1 (IGF-1) receptors is demonstrated in the myometrium, a pathogenetic role of GH in the development of myoma is examined through different studies. Moreover, some of them ...

A diagnosis of primary amenorrhea (PA) is always a clinical challenge. By definition, PA is a failure to reach menarche by age 14 with the absence of secondary sexual characteristics or absence of menses by age 16 years regardless of the development of secondary sexual characteristics. It may result from a number of different conditions and requires comprehensive evaluation to identify a cause, along with a regular patient follow-up. The aim of this case report is to emphasize...

Introduction and objective: The research was conducted with the aim of highlighting the awareness and understanding of the disease among diabetic patients.Methods: The study included 85 patients with type 2 diabetes, aged 40+ years old, who had been monitoring their blood glucose levels and HbA1c levels in the previous 4 months. Patients were presented a questionnaire with 5 questions about diabetes. The patients’ responses were classified and expre...

Impaired growth hormone (GH) secretion occurs in patients with Cushing’s disease (CD) as a result of cortisol excess. After a surgical treatment, eventually accompanied with radiation therapy, recovery of GH secretion is seen in only variable proportion of patients. According to some studies, it is recommended to perform assessment of GH secretion one to two years after surgical cure of CD. We report a case of a 40-years-old male admitted to the hospital because of sudden...

Objective: To evaluate and compare the effects of metformin used as a single-agent therapy and in combination with gliclazide modified release (MR) on glycoregulation and lipid profile in patients with type 2 diabetes mellitus (T2DM).Methodology: A multi-center observational epidemiological study was carried out in patients with T2DM, divided in two groups according to the current type of treatment: first group was on monotherapy with metformin in daily ...

Background: Due to its efficacy and safety, metformin is the most commonly used drug in a single-agent therapy of type 2 diabetes mellitus (T2DM), after lifestyle modifications failed to obtain a desirable effects. Despite his main effects in improving glycemic control, it is also stated that it has a beneficial effects on lipid profile, which may be attributable to improved insulin sensitivity, weight loss and reduction of irreversibly glycated low density lipoprotein cholest...